- Ketamine Introduction Ketamine was first synthesized in 1962 by Calvin Stevens at Parke-Davis Co (now Pfizer) as an alternative anesthetic to phencyclidine.
It was first used in humans in 1965 by Corssen and Domino and was introduced into clinical practice by 1970. Ketamine is frequently described as
a “unique drug” because it shows hypnotic (sleep-producing), analgesic (pain-relieving) and amnesic (short-term memory loss) effects; no other
drug used in clinical practice produces these three important effects at the same time.
- Mood Disorders
- Chronic Pain
- Bi Bolar
Severe depression is a disorder that can most often be improved with present day oral antidepressants. These drugs generally work by increasing the amount of serotonin or norepinepherine in the brain. While effective in most patients, these medications can take weeks to begin working. In addition, your physician may have to try several different antidepressants before finding the right medication or combination that will help. Ppatients with severe depression,and/or those having thoughts of self harm, the wait may be too long, for those, immediate relief of their depression could be life saving. Until now, electro convulsive therapy (ECT) has been the only proven method of treating severe and life threatening depression with minimal delay.
For over a decade scientists have been studying the role of another neurotransmitter, glutamate, and its role in understanding depression. It has now been proven that the administration of subanesthetic doses of ketamine, a glutamate (NMDA) receptor antagonist, results in a dramatic and rapid improvement in severe depression.
It is often used for:
Ketamine is not a cure, however, it may provide patients with an extended period of relief from treatment resistant symptoms. Contact us to learn how Ketamine offers hope to people suffering from some of the symptoms listed above.
Types of Mood Disorders
Depression and anxiety are considered to be mood disorders that can severely disrupt your life. Potential candidates for Ketamine infusion therapy may have previous diagnoses of the following:
* Major Depressive Disorders
* Post-partum Depression
* Bi-polar Depression
* Severe Anxiety
When you’re in pain, nothing else matters. If you have chronic pain, your life is completely interrupted. It doesn’t take long for your quality of life to suffer due to pain. At LIMA Lubbock, we want to help you get your full life back. That’s why we’ve developed protocols for infusion therapy that will help alleviate your pain and get you back on your feet again.
- * Chronic migraines
* Diabetic Neuropathy
* Chronic Inflammation
The infusions take place in private rooms, in out-patient office setting. Patients sit in a comfortable reclining chair. The infusion takes about one hour depending on patients needs and treatment. Patients generally stay another 15-30 minutes before leaving, but may stay until they feel comfortable leaving. Patients are encouraged to be accompanied for at least the first visit. During the infusion patients also are encouraged to listen to music they enjoy from their own play lists. Wi-Fi available. During the infusion you will experience some dissociation, which are not hallucinations, but rather altered reality. Most patients find it pleasurable and non-threatening. If it does make you uncomfortable the infusion can be stopped, or medication given which will end the thoughts within a minute. It is rare that this is necessary. By the time you leave the office your mentation will be close to normal. Some patients are able to return to work, go to airports etc., and carry on an otherwise normal day. Other patients prefer to go home and take a short nap. The only restriction after leaving the office is no driving until the next day. You must have a designated driver when leaving the office after an infusion. Your improvement in mood will not be immediate. The earliest that you might expect to feel better is several hours after leaving the office.
We are one of the only offices registered with American Society of Ketamine Physicians in The Panhandle. (nearest is Dallas area)
A few facts for you
What is Ketamine?
Ketamine was first, and still is, an important human general anesthetic agent. It has been used in hospitals for the past five decades and has
a proven record of safety. More recently it is being used to treat neuropathic pain and the symptoms of PTSD. The small doses and methods of
administration used to treat psychiatric patients differ greatly from those used in hospitals.
Ketamine is on the World Health Organizations’s list of “Top 10 Essential Drugs”
Is this treatment FDA approved?
Not yet. Over the past two decades dozens of studies in prestigious medical centers and The National Institute of Mental Health have proven ketamine’s safety and efficacy in treating major depressive disorders, anxiety, obsessive compulsive disorders and suicide ideation. Yet, without very large controlled studies generally required by the FDA to get approval for any psychiatric drug, approval has been delayed. Since ketamine is a generic drug, no pharmaceutical company will spent the hundreds of millions of dollars required for such a study. Efforts are being made to create a national registry of the outcomes of the thousands of patients treated by ketamine providers across the country to date. This data will be used to expedite FDA approval. In the meantime, ketamine is being used “off label”, as is true with many other medications prescribed by physicians.
Will I be treated as an outpatient?
Yes, ketamine infusions for depression are outpatient procedures requiring no hospital admission.
Do I need a referral from a psychiatrist?
No, while referrals from any mental health care provider are welcome and encouraged, an initial phone interview with one of our doctors can determine if you are a good candidate for ketamine therapy.
Is ketamine used to treat all patients with depression?
No, mild to moderate depression is successfully treated by mental health professionals with drugs and psychotherapy. The treatment of severe depression is more difficult and requires a higher level of care, such as ECT, TMS, and now ketamine therapy. Ketamine infusion therapy is reserved for those patients with severe depression that is considered otherwise treatment resistant.
Is it likely that my severe depression will respond to ketamine infusion therapy?
The patients we see are all considered treatment resistant. That is, they have not responded to available antidepressant medications and in many cases have not responded to ECT or TMS. We cannot predict who will respond to ketamine, but statistically 2 out of 3 patients do show a dramatic improvement in their mood and 3 out of 4 will cease to have suicide ideation. We will know within two treatments if ketamine infusions will help you.
How many infusions will I need and how long will I feel better?
If you have a favorable response to the first two infusions, a total of six is recommended within a twelve day period. That will maximize the ketamine effect on new dendrite and synapse growth. Thereafter, patients are placed a maintenance program where they return when they feel it necessary for a single infusion booster. During the maintenance period, the duration of relief following the initial infusions and the first booster, and between subsequent single booster infusions varies between patients. The average duration of relief between booster infusions is 3 to 4 weeks. There is no way to predict what your needs will be.
If ketamine does work, will I be on it for the rest of my life?
No, right now ketamine infusion therapy is, perhaps, the most exciting and successful new treatment for severe depression. But, there are large pharmaceutical companies developing ketamine like drugs for more convenient nasal and oral administration. It may be a few years, but those drugs will become available. In the meantime, ketamine has been proven effective in most cases, and is available to you or your loved ones. Patients with debilitating severe depression with constant thoughts of self harm can not afford to wait.
How long does an infusion take?
About an hour, with an additional half hour before discharge.
Will I be asleep?
No. The dose of ketamine you will receive does not cause any loss of consciousness.
What will I experience during the infusion?
Most patients experience a mild dissociation or inner reflective experience that is generally well tolerated. If you find it unpleasant we can treat it. Within 15 minutes of ending the infusion your thinking will be clear. There are no delayed “flashbacks.”
Are there any medications that will interfere with ketamine treatment?
Yes. The benzodiazepines, such as Klonopin, Xanax, and Ativan do interfere with ketamine if used daily and at higher doses. Lamictal (lamotrigine) in doses above 100mg/day also can block ketamine efficacy.
Will I have to stop other antidepressant medications?
No, other antidepressant medications do not interfere with ketamine’s mechanism of action.
Are there any medical conditions that will exclude me from treatment?
Almost none. Uncontrolled high blood pressure or heart failure need to be corrected.
Should I be concerned about any risks or addiction with ketamine therapy?
No, ketamine has been proven safe in humans over five decades in and out of hospitals and battle fields for surgical anesthesia and trauma management. Those patients experience longer exposures and at much higher doses than those used to treat severe depression. Although it has been abused recreationally in high doses as a club drug, there is no evidence that ketamine is addictive.
How quickly can I be seen?
In general, five to seven days are required to get you on the schedule. Since we will need documentation prior to treatment, either from our office or your provider it could delay when you are put on the schedule.
Here are links to the paper work that you will need fill out prior to your appointment. You can download them and email them back to our office at email@example.com or bring them in with you at the time of your appointment.
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